PSYE402 Methodology of Psychophysiological Experiments


The course introduces the main neuroimaging psychophysiological methods used to study the brain function in relation to the human cognitive and affective processes.

The course covers several neuroimaging techniques – Magnetic Resonance Imaging (MRI), functional MRI (fMRI), Positron Emission Tomography (PET), as well as several psychophysiological methods, such as single cell recordings, recording of Local Field Potentials (LFP), Electro Encephalography (EEG), Magneto Encephalography (MEG), and Polygraph recordings (skin-galvanic potentials, Electro-Cardiogram (ECG), Electro-Myogram (EMG)). The course includes several practical exercises in the Neuroscience Lab.

Additionally, a lot of attention is devoted to the technology of planning and conducting psychophysiological experiments. The topics include the main methods for psychophysiological studies, data analysis and interpretation.

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Psychology (in English)


Prof. Maurice Grinberg, PhD
Asst. Prof. Armine Janyan, PhD
Assist. Prof. Evgenia Hristova, PhD
Asst. Prof Veselina Kadreva, PhD
Asst. Prof. Ivo Popivanov, PhD

Course Description:


Upon the successful completion of the course the students will:


• the main psycho-physiological methods for studying human cognitive processes

• the main neuroimaging and psychophysiological methods for studying human cognitive processes

• the main psychophysiological methods for studying emotions


• critically analyze the advantages and disadvantages of each method

• understand and evaluate scientific neuroimaging and psychophysiological stud
• An introductory course in neuroscience (PSYE209, PSYE210, PSYE301)

• An introductory course in experimental psychology/cognitive science (PSYE101, PSYE102, PSYE211, PSYE212)

• A course in statistics (PSYE107, PSYE108)

Full-time Programmes

Types of Courses:

Language of teaching:


  1. Introduction to neuroimaging and psychophysiology.
  2. Single unit electrophysiology. Recordings in humans and nonhuman primates.
  3. EEG basics. Recording EEG. Electrodes placement. Montages. Artifacts
  4. EEG recordings – practical excercise.
  5. Analyzing EEG: Event-related potentials
  6. Analyzing EEG: frequency bands
  7. Techniques between single cell recordings and EEG – EcoG, LFP
  8. Usage of electrophysiolgical techniques in Brain-Computer Interfaces (BCIs)
  9. Test on topics 1-8
  10. Psycho-physiological signals in the study of emotions.
  11. Recording SGR, EKG, PPG, EMG – practical excercise.
  12. Lie detection.
  13. Functional imaging of the brain – fMRI, PET.
  14. Analysis, limitations and interpretation of functional neuroimaging data.
  15. Final seminar with presentations of experimental designs with neuroimaging or psychophysiological technique


Core readings

• Dickter, C. L., & Kieffaber, P. D. (2013). EEG methods for the psychological sciences. Sage.

• Senior, C., Russel, T., Gazzaniga, M. (2009). Methods in Mind. MIT Press.

• Schomer, D.L. & Lopes da Silva, F.H. (2011). Niedermeyer’s Electroencephalography. Basic principles, Clinical Applications, and Related Fields. Sixth edition. Lippincott Williams & Wilkins

Additional readings

• Andreassi, J. (2006). Psychophysiology: Human Behavior and Physiological Responses. Lawrence Erlbaum Associates.

• Cacioppo, J., Tassinary, L., Berntson, G. (eds.) (2007). Handbook of psychophysiology. 3rd ed. Cambrige Univ Press.